Structure of PDB 6e59 Chain A

Receptor sequence
>6e59A (length=479) Species: 9606,272844 [Search protein sequence]
PAWQIVLWAAAYTVIVVTSVVGNVVVMWIILAHKRMRTVTNYFLVNLAFA
EASMAAFNTVVNFTYAVHNEWYYGLFYCKFHNFFPIAAVFASIYSMTAVA
FDRYMAIIHPLQPRLSATATKVVICVIWVLALLLAFPQGYYSTTETMPSR
VVCMIEWPEHPNKIYEKVYHICVTVLIYFLPLLVIGYAYTVVGITLWASE
GIDCSFWNESYLTGSRDERKKSLLSKFGMDEGVTFMFIGRFDRGQKGVDV
LLKAIEILSSKKEFQEMRFIIIGKGDPELEGWARSLEEKHGNVKVITEML
SREFVRELYGSVDFVIIPSYFEPFGLVALEAMCLGAIPIASAVGGLRDII
TNETGILVKAGDPGELANAILKALELSRSDLSKFRENCKKRAMSFSEQVS
AKRKVVKMMIVVVCTFAICWLPFHIFFLLPYINPDLYLKKFIQQVYLAIM
WLAMSSTMYNPIIYCCLNDRFRLGFKHAF
3D structure
PDB6e59 Crystal structure of the human NK1tachykinin receptor.
ChainA
Resolution3.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 L76 A N109 P112 I113 V116 Q165 E193 H197 I204 F264 F268 N82 P85 I86 V89 Q138 E166 H170 I177 F423 F427 PDBbind-CN: -logKd/Ki=8.67,Kd=2.15nM
Gene Ontology
Molecular Function
GO:0004930 G protein-coupled receptor activity
GO:0004995 tachykinin receptor activity
Biological Process
GO:0007186 G protein-coupled receptor signaling pathway
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6e59, PDBe:6e59, PDBj:6e59
PDBsum6e59
PubMed30538204
UniProtP25103|NK1R_HUMAN Substance-P receptor (Gene Name=TACR1);
Q9V2J8

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