Structure of PDB 6e54 Chain A

Receptor sequence

>6e54A (length=300) Species: 208964 (Pseudomonas aeruginosa PAO1) [Search protein sequence]

SMIKQRTLKNIIRATGVGLHSGEKVYLTLKPAPVDTGIVFCRTDLDPVVE
IPARAENVGETTMSTTLVKGDVKVDTVEHLLSAMAGLGIDNAYVELSASE
VPIMDGSAGPFVFLIQSAGLQEQEAAKKFIRIKREVSVEEGDKRAVFVPF
DGFKVSFEIDFDHPVFRGRTQQASVDFSSTSFVKEVSRARTFGFMRDIEY
LRSQNLALGGSVENAIVVDENRVLNEDGLRYEDEFVKHKILDAIGDLYLL
GNSLIGEFRGFKSGHALNNQLLRTLIADKDAWEVVTFEDARTAPISYMRP

3D structure

PDB

6e54 Crystal structure of LpxC from Pseudomonas aeruginosa in complex with ligand PT802

Chain

Resolution

1.65 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

3.5.1.108: UDP-3-O-acyl-N-acetylglucosamine deacetylase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	HUM	A	L18 M62 E77 T190 F191 G192 F193 M194 I197 G209 H237 D241 H264	L19 M63 E78 T191 F192 G193 F194 M195 I198 G210 H238 D242 H265
BS02	JCG	A	L18 M62 E77 T190 F191 G192 F193 M194 I197 L200 V216 H237 K238 D241 H264	L19 M63 E78 T191 F192 G193 F194 M195 I198 L201 V217 H238 K239 D242 H265
BS03	ZN	A	H78 H237 D241	H79 H238 D242

Gene Ontology

	Molecular Function
GO:0016787	hydrolase activity
GO:0046872	metal ion binding
GO:0103117	UDP-3-O-acyl-N-acetylglucosamine deacetylase activity

	Biological Process
GO:0006796	phosphate-containing compound metabolic process
GO:0009245	lipid A biosynthetic process
GO:0019637	organophosphate metabolic process
GO:1901135	carbohydrate derivative metabolic process

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Molecular Function

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Biological Process

External links

PDB	RCSB:6e54, PDBe:6e54, PDBj:6e54
PDBsum	6e54
PubMed
UniProt	P47205\|LPXC_PSEAE UDP-3-O-acyl-N-acetylglucosamine deacetylase (Gene Name=lpxC)

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