Structure of PDB 6e4v Chain A

Receptor sequence
>6e4vA (length=672) Species: 679895 (Escherichia coli BW25113) [Search protein sequence]
NDYSVTSTSAGTKMQMTQRDIPQSVTIVSQQRMEDQQLQTLGEVMENTLG
ISKSQADSDRALYYSRGFQIDNYMVDGIPTYFESRWNLGDALSDMALFER
VEVVRGATGLMTGTGNPSAAINMVRKHATSREFKGDVSAEYGSWNKERYV
ADLQSPLTEDGKIRARIVGGYQNNDSWLDRYNSEKTFFSGIVDADLGDLT
TLSAGYEYQRIDVNSPTWGGLPRWNTDGSSNSYDRARSTAPDWAYNDKEI
NKVFMTLKQQFADTWQATLNATHSEVEFDSKMMYVDAYVNKADGMLVGPY
SNYGPGFDYVGGTGWNSGKRKVDALDLFADGSYELFGRQHNLMFGGSYSK
QNNRYFSSWANIFPDEIGSFYNFNGNFPQTDWSPQSLAQDDTTHMKSLYA
ATRVTLADPLHLILGARYTNWRVDTLTYSMEKNHTTPYAGLVFDINDNWS
TYASYTSIFQPQNDRDSSGKYLAPITGNNYELGLKSDWMNSRLTTTLAIF
RIEQDNVAQSTGTPIPGSNGETAYKAVDGTVSKGVEFELNGAITDNWQLT
FGATRYIAEDNEGNAVNPNLPRTTVKMFTSYRLPVMPELTVGGGVNWQNR
VYTDTVTPYGTFRAEQGSYALVDLFTRYQVTKNFSLQGNVNNLFDKTYDT
NVEGSIVYGTPRNFSITGTYQF
3D structure
PDB6e4v Determination of the molecular basis for coprogen import by Gram-negative bacteria.
ChainA
Resolution2.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 HWS A R117 L119 R142 W143 W275 Y341 D343 N373 W416 R60 L62 R85 W86 W218 Y284 D286 N316 W359 PDBbind-CN: -logKd/Ki=6.29,Kd=508nM
Gene Ontology
Molecular Function
GO:0015092 high-affinity ferric iron transmembrane transporter activity
GO:0015343 siderophore-iron transmembrane transporter activity
GO:0015344 siderophore uptake transmembrane transporter activity
GO:0038023 signaling receptor activity
Biological Process
GO:0006826 iron ion transport
GO:0006879 intracellular iron ion homeostasis
GO:0015687 ferric-hydroxamate import into cell
GO:0015891 siderophore transport
GO:0033214 siderophore-dependent iron import into cell
GO:0042928 ferrichrome import into cell
GO:0044718 siderophore transmembrane transport
GO:0072711 cellular response to hydroxyurea
Cellular Component
GO:0009279 cell outer membrane
GO:0016020 membrane
GO:1902495 transmembrane transporter complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6e4v, PDBe:6e4v, PDBj:6e4v
PDBsum6e4v
PubMed31098021
UniProtP16869|FHUE_ECOLI Hydroxamate siderophore receptor FhuE (Gene Name=fhuE)

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