Structure of PDB 6e3p Chain A

Receptor sequence
>6e3pA (length=174) Species: 641501 (Influenza A virus (A/California/04/2009(H1N1))) [Search protein sequence]
AMEDFVRQCFNPMIVELAEKAMKEYGEDPKIETNKFAAICTHLEVCFMYS
DFGHRFEIIEGRDRIMAWTVVNSICNTTGVEKPKFLPDLYDYKENRFIEI
GVTRREVHIYYLEKANKIEKTHIHIFSFTGEEMATKADYTLDEESRARIK
TRLFTIRQEMASRSLWDSFRQSER
3D structure
PDB6e3p SAR Exploration of Tight-Binding Inhibitors of Influenza Virus PA Endonuclease.
ChainA
Resolution2.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.-.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MN A H41 D108 E119 I120 H42 D88 E99 I100
BS02 MN A E80 D108 E60 D88
BS03 HO1 A H41 E80 D108 E119 Y130 K134 E195 R196 H42 E60 D88 E99 Y110 K114 E173 R174 PDBbind-CN: -logKd/Ki=8.70,IC50<2nM
BS04 HO1 A K34 A37 I38 H41 E80 R124 K35 A38 I39 H42 E60 R104 PDBbind-CN: -logKd/Ki=8.70,IC50<2nM
Gene Ontology
Biological Process
GO:0039694 viral RNA genome replication

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Molecular Function
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Biological Process
External links
PDB RCSB:6e3p, PDBe:6e3p, PDBj:6e3p
PDBsum6e3p
PubMed31536340
UniProtC3W5S0

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