Structure of PDB 6e3o Chain A

Receptor sequence
>6e3oA (length=175) Species: 641501 (Influenza A virus (A/California/04/2009(H1N1))) [Search protein sequence]
AMEDFVRQCFNPMIVELAEKAMKEYGEDPKIETNKFAAICTHLEVCFMYS
DFGLKHRFEIIEGRDRIMAWTVVNSICNTTGVEKPKFLPDLYDYKENRFI
EIGVTRREVHIYYLEKANKIEKTHIHIFSFTGEEMATKADYTLDEESRAR
IKTRLFTIRQEMASRSLWDSFRQSE
3D structure
PDB6e3o SAR Exploration of Tight-Binding Inhibitors of Influenza Virus PA Endonuclease.
ChainA
Resolution3.19 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.-.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MN A H41 D108 E119 I120 H42 D90 E101 I102
BS02 MN A E80 D108 E119 E62 D90 E101
BS03 HNY A K34 H41 E80 D108 E119 K134 K35 H42 E62 D90 E101 K116 PDBbind-CN: -logKd/Ki=8.70,IC50<2nM
Gene Ontology
Biological Process
GO:0039694 viral RNA genome replication

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Molecular Function
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Biological Process
External links
PDB RCSB:6e3o, PDBe:6e3o, PDBj:6e3o
PDBsum6e3o
PubMed31536340
UniProtC3W5S0

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