Structure of PDB 6e37 Chain A

Receptor sequence

>6e37A (length=692) Species: 9606 (Homo sapiens)

PTHADSLNNLANIKREQGNIEEAVRLYRKALEVFPEFAAAHSNLASVLQQ
QGKLQEALMHYKEAIRISPTFADAYSNMGNTLKEMQDVQGALQCYTRAIQ
INPAFADAHSNLASIHKDSGNIPEAIASYRTALKLKPDFPDAYCNLAHCL
QIVCDWTDYDERMKKLVSIVADQLEKNRLPSVHPHHSMLYPLSHGFRKAI
AERHGNLCLDKINVLHKPPYEHPKDLKLSDGRLRVGYVSSDFGNHPTSHL
MQSIPGMHNPDKFEVFCYALSPDDGTNFRVKVMAEANHFIDLSQIPCNGK
AADRIHQDGIHILVNMNGYTKGARNELFALRPAPIQAMWLGYPGTSGALF
MDYIITDQETSPAEVAEQYSEKLAYMPHTFFIGDHANMFPHLKKKAVIDF
HIYDNRIVLNGIDLKAFLDSLPDVKIVNMPVIPMNTIAEAVIEMINRGQI
QITINGFSISNGLATTQINNKAATGEEVPRTIIVTTRSQYGLPEDAIVYC
NFNQLYKIDPSTLQMWANILKRVPNSVLWLLRFPAVGEPNIQQYAQNMGL
PQNRIIFSPVAPKEEHVRRGQLADVCLDTPLCNGHTTGMDVLWAGTPMVT
MPGETLASRVAASQLTCLGCLELIAKNRQEYEDIAVKLGTDLEYLKKVRG
KVWKQRISSPLFNTKQYTMELERLYLQMWEHYAAGNKPDHMI

3D structure

• PDB: 6e37 Targeted covalent inhibition of O-GlcNAc transferase in cells.
• Chain: A
• Resolution: 2.531 Å

Enzymatic activity

• Enzyme Commision number: 2.4.1.255: protein O-GlcNAc transferase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	A	H496 N557 P559 Y632 T633 K634 Q839 V895 P897	H183 N244 P246 Y319 T320 K321 Q504 V560 P562
BS02	HQV	A	P559 T560 L563 P656 F694 Y841 K842 L866 V895 A896 K898 H901 C917 H920 T921 T922 D925	P246 T247 L250 P343 F381 Y506 K507 L531 V560 A561 K563 H566 C582 H585 T586 T587 D590

External links

• PDB: RCSB:6e37, PDBe:6e37, PDBj:6e37
• PDBsum: 6e37
• PubMed: 31626249
• UniProt: O15294|OGT1_HUMAN UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit (Gene Name=OGT)