Structure of PDB 6e0q Chain A

Receptor sequence
>6e0qA (length=178) Species: 641501 (Influenza A virus (A/California/04/2009(H1N1))) [Search protein sequence]
AMEDFVRQCFNPMIVELAEKAMKEYGEDPKIETNKFAAICTHLEVCFMYS
DFGHRFEIIEGRDRIMAWTVVNSICNTTGVEKPKFLPDLYDYKENRFIEI
GVTRREVHIYYLEKANKIKSEKTHIHIFSFTGEEMATKADYTLDEESRAR
IKTRLFTIRQEMASRSLWDSFRQSERGE
3D structure
PDB6e0q Structure-Activity Relationships in Metal-Binding Pharmacophores for Influenza Endonuclease.
ChainA
Resolution2.35 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.-.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MN A H41 D108 E119 I120 H42 D88 E99 I100
BS02 MN A E80 D108 E60 D88
BS03 HKD A H41 E80 D108 E119 K134 E198 H42 E60 D88 E99 K114 E178 MOAD: ic50=8nM
PDBbind-CN: -logKd/Ki=8.10,IC50=8.0nM
Gene Ontology
Biological Process
GO:0039694 viral RNA genome replication

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Molecular Function
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Biological Process
External links
PDB RCSB:6e0q, PDBe:6e0q, PDBj:6e0q
PDBsum6e0q
PubMed30351002
UniProtC3W5S0

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