Structure of PDB 6e0n Chain A

Receptor sequence
>6e0nA (length=271) Species: 1216967 (Elizabethkingia meningoseptica ATCC 13253 = NBRC 12535) [Search protein sequence]
NFSEQQLINWSRPVSTTEDLKCQNAITQITAALRAKFGNRVTIFLQGSYR
NNTNVRQNSDVDIVMRYDDAFYPDLYNFDELKADTEEALRNVFTTSVERK
NKCIQVNGNSNRITADVIPCFVLKRFSTLQSVEAEGIKFYSDDNKEIISF
PEQHYSNGTEKTNQTYRLYKRMVRILKVVNYRLIDDGEIADNLVSSFFIE
CLVYNVPNNQFISGNYTQTLRNVIVKIYEDMKNNADYTEVNRLFWLFSNR
SPRTRQDALGFMQKCWNYLGY
3D structure
PDB6e0n Bacterial cGAS-like enzymes synthesize diverse nucleotide signals.
ChainA
Resolution1.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.-
2.7.7.65: diguanylate cyclase.
2.7.7.85: diadenylate cyclase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 APC A Q47 D63 K120 N121 K122 C123 I138 F159 I167 S169 Q46 D62 K100 N101 K102 C103 I118 F139 I147 S149
BS02 GTP A Q47 G48 S49 D63 K197 S216 F217 Q46 G47 S48 D62 K177 S196 F197
BS03 GTP A P14 N53 R187 R191 R194 P13 N52 R167 R171 R174
Gene Ontology
Molecular Function
GO:0005524 ATP binding
GO:0005525 GTP binding
GO:0016779 nucleotidyltransferase activity
GO:0046872 metal ion binding
GO:0052621 diguanylate cyclase activity
GO:0106408 diadenylate cyclase activity
GO:0140701 3',3'-cyclic GMP-AMP synthase activity
Biological Process
GO:0009117 nucleotide metabolic process
GO:0051607 defense response to virus

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Molecular Function
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Biological Process
External links
PDB RCSB:6e0n, PDBe:6e0n, PDBj:6e0n
PDBsum6e0n
PubMed30787435
UniProtA0A4V8GZR7

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