Structure of PDB 6dzy Chain A

Receptor sequence
>6dzyA (length=537) Species: 9606 (Homo sapiens) [Search protein sequence]
RETWGKKVDFLLSVIGYAVDLGNVWRFPYICYQNGGGAFLLPYTIMAIFG
GIPLFYMELALGQYHRNGCISIWRKICPIFKGIGYAICIIAFYIASYYNT
IMAWALYYLISSFTDQLPWTSCKNSWNTGNCTNYFSEDNITWTLHSTSPA
EEFYTRHVLQIHRSKGLQDLGGISWQLALCIMLIFTVIYFSIWKGVKTSG
KVVWVTATFPYIALSVLLVRGATLPGAWRGVLFYLKPNWQKLLETGVWID
AAAQIFFSLGPGFGVLLAFASYNKFNNNCYQDALVTSVVNCMTSFVSGFV
IFTVLGYMAEMRNEDVSEVAKDAGPSLLFITYAEAIANMPASTFFAIIFF
LMLITLGLDSSFAGLEGVITAVLDEFPHVWAKRRERFVLAVVITCFFGSL
VTLTFGGAYVVKLLEEYATGPAVLTVALIEAVAVSWFYGITQFCRDVKEM
LGFSPGWFWRICWVAISPLFLLFIIASFLMSPPQLRLFQYNYPYWSIILG
YAIGTSSFICIPTYIAYRLIITPGTFKERIIKSITPE
3D structure
PDB6dzy Serotonin transporter-ibogaine complexes illuminate mechanisms of inhibition and transport.
ChainA
Resolution4.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 HJM A Y95 A96 D98 I172 A173 Y176 F335 F341 G442 L443 Y17 A18 D20 I94 A95 Y98 F257 F263 G364 L365 PDBbind-CN: -logKd/Ki=5.52,Ki=3uM
Gene Ontology

View graph for
Cellular Component
External links
PDB RCSB:6dzy, PDBe:6dzy, PDBj:6dzy
PDBsum6dzy
PubMed31019304
UniProtP31645|SC6A4_HUMAN Sodium-dependent serotonin transporter (Gene Name=SLC6A4)

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