Structure of PDB 6dxl Chain A

Receptor sequence
>6dxlA (length=177) Species: 9606 (Homo sapiens) [Search protein sequence]
FNVAHGLAWSYYIGYLRLILPELQARIRTYNQHYNNLLRGAVSQRLYILL
PLDCGVPDNLSMADPNIRFLDKLPQQYSNSIYELLENGQRAGTCVLEYAT
PLQTLFAMSQYSQAGFSREDRLEQAKLFCRTLEDILADAPESQNNCRLIA
YQEPADFSLSQEVLRHLRQEEKEEVTV
3D structure
PDB6dxl Design of amidobenzimidazole STING receptor agonists with systemic activity.
ChainA
Resolution2.45 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 HG4 A S162 Y163 Y167 S241 T263 P264 S10 Y11 Y15 S78 T100 P101 MOAD: Kd=1.6nM
PDBbind-CN: -logKd/Ki=5.80,Kd=1.6uM
BS02 CA A D205 E316 D53 E153
Gene Ontology
Biological Process
GO:0002218 activation of innate immune response
GO:0032481 positive regulation of type I interferon production

View graph for
Biological Process
External links
PDB RCSB:6dxl, PDBe:6dxl, PDBj:6dxl
PDBsum6dxl
PubMed30405246
UniProtQ86WV6|STING_HUMAN Stimulator of interferon genes protein (Gene Name=STING1)

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