Structure of PDB 6dxh Chain A

Receptor sequence
>6dxhA (length=117) Species: 9606 (Homo sapiens) [Search protein sequence]
VRQVSKHAFSLKQLDNPARIPPCGWKCSKCDMRENLWLNLTDGSILCGRR
YFDGSGGNNHAVEHYRETGYPLAVKLGTITPDGADVYSYDEDDMVLDPSL
AEHLSHFGIDMLKMQKT
3D structure
PDB6dxh Discovery of Small Molecule Antagonists of the USP5 Zinc Finger Ubiquitin-Binding Domain.
ChainA
Resolution2.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.19.12: ubiquitinyl hydrolase 1.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A C199 C202 C219 H232 C27 C30 C47 H60
BS02 HH4 A W209 G220 R221 Y259 Y261 W37 G48 R49 Y87 Y89 BindingDB: Kd=170000nM
Gene Ontology
Molecular Function
GO:0008270 zinc ion binding

View graph for
Molecular Function
External links
PDB RCSB:6dxh, PDBe:6dxh, PDBj:6dxh
PDBsum6dxh
PubMed31663737
UniProtP45974|UBP5_HUMAN Ubiquitin carboxyl-terminal hydrolase 5 (Gene Name=USP5)

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