Structure of PDB 6dxg Chain A

Receptor sequence
>6dxgA (length=177) Species: 9606 (Homo sapiens) [Search protein sequence]
FNVAHGLAWSYYIGYLRLILPELQARIRTYNQHYNNLLRGAVSQRLYILL
PLDCGVPDNLSMADPNIRFLDKLPQQVYSNSIYELLENGQRAGTCVLEYA
TPLQTLFAMSQYSQAGFSREDRLEQAKLFCRTLEDILADAPESQNNCRLI
AYQEPAFSLSQEVLRHLRQEEKEEVTV
3D structure
PDB6dxg Design of amidobenzimidazole STING receptor agonists with systemic activity.
ChainA
Resolution1.905 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA A D205 E316 D53 E154
BS02 HGJ A L159 S162 Y163 Y167 Y240 S241 T263 P264 L7 S10 Y11 Y15 Y78 S79 T101 P102 MOAD: ic50=14uM
PDBbind-CN: -logKd/Ki=4.85,IC50=14uM
Gene Ontology
Biological Process
GO:0002218 activation of innate immune response
GO:0032481 positive regulation of type I interferon production

View graph for
Biological Process
External links
PDB RCSB:6dxg, PDBe:6dxg, PDBj:6dxg
PDBsum6dxg
PubMed30405246
UniProtQ86WV6|STING_HUMAN Stimulator of interferon genes protein (Gene Name=STING1)

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