Structure of PDB 6dwk Chain A

Receptor sequence

>6dwkA (length=480) Species: 9606 (Homo sapiens) [Search protein sequence]

DTMKVINDPIHGHIELHPLLVRIIDTPQFQRLRYIKQLGGGYYVFPGASH
NRFEHSLGVGYLAGCLVHALGEKQPELQISERDVLCVQIAGLCRNLGHGP
FSHMFDGRFIPLARPEVKWTHEQGSVMMFEHLINSNGIKPVMEQYGLIPE
EDICFIKEQIVGPLELWPYKGRPENKSFLYEIVSNKRNGIDVDKWDYFAR
DCHHLGIQNNFDYKRFIKFARVCEVDNELRICARDKEVGNLYDMFHTRNS
LHRRAYQHKVGNIIDTMITDAFLKADDYIEITGAGGKKYRISTAIDDMEA
YTKLTDNIFLEILYSTDPKLKDAREILKQIEYRNLFKYVGETQPTGQIKI
KREDYESLPKEVASAKPKVLLDVKLKAEDFIVDVINMDYGMQEKNPIDHV
SFYCKTAPNRAIRITKNQVSQLLPEKFAEQLIRVYCKKVDRKSLYAARQY
FVQWCADRNFTKPQDGDVIAPLITPQKKEW

3D structure

PDB

6dwk The structural basis for cancer drug interactions with the catalytic and allosteric sites of SAMHD1.

Chain

Resolution

2.3 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

3.1.5.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	HFD	A	Q149 L150 R164 H215 H233 K312 Y315 D319 R366 H370 Y374	Q37 L38 R52 H103 H121 K194 Y197 D201 R248 H252 Y256
BS02	GTP	A	Y155 V156 V378 R451	Y43 V44 V260 R333
BS03	DTP	A	R333 R352 K354 N358 K523	R215 R234 K236 N240 K405
BS04	GTP	A	K116 V117 I118 D137 Q142 R145	K4 V5 I6 D25 Q30 R33
BS05	MG	A	D309 K312	D191 K194
BS06	GLY	A	R366 H370 N504 D506	R248 H252 N386 D388
BS07	DTP	A	V117 N119	V5 N7
BS08	DTP	A	V156 F157 R372 H376 K377	V44 F45 R254 H258 K259

External links

PDB	RCSB:6dwk, PDBe:6dwk, PDBj:6dwk
PDBsum	6dwk
PubMed	30305425
UniProt	Q9Y3Z3\|SAMH1_HUMAN Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 (Gene Name=SAMHD1)

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