Structure of PDB 6dwj Chain A

Receptor sequence

>6dwjA (length=481) Species: 9606 (Homo sapiens) [Search protein sequence]

DTMKVINDPIHGHIELHPLLVRIIDTPQFQRLRYIKQLGGGYYVFPGASH
NRFEHSLGVGYLAGCLVHALGEKQPELQISERDVLCVQIAGLCRNLGHGP
FSHMFDGRFIPLARPEVKWTHEQGSVMMFEHLINSNGIKPVMEQYGLIPE
EDICFIKEQIVGPLELWPYKGRPENKSFLYEIVSNKRNGIDVDKWDYFAR
DCHHLGIQNNFDYKRFIKFARVCEVDNELRICARDKEVGNLYDMFHTRNS
LHRRAYQHKVGNIIDTMITDAFLKADDYIEITGAGGKKYRISTAIDDMEA
YTKLTDNIFLEILYSTDPKLKDAREILKQIEYRNLFKYVGETQPTGQIKI
KREDYESLPKEVASAKPKVLLDVKLKAEDFIVDVINMDYGMQEKNPIDHV
SFYCKTAPNRAIRITKNQVSQLLPEKFAEQLIRVYCKKVDRKSLYAARQY
FVQWCADRNFTKPQDGDVIAPLITPQKKEWN

3D structure

PDB

6dwj The structural basis for cancer drug interactions with the catalytic and allosteric sites of SAMHD1.

Chain

Resolution

2.5 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

3.1.5.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	GTP	A	K116 V117 I118 D137 R145	K4 V5 I6 D25 R33
BS02	GTP	A	Y155 V156 V378 R451	Y43 V44 V260 R333
BS03	DTP	A	V156 F157 H376 K377	V44 F45 H258 K259
BS04	DTP	A	V117 N119	V5 N7
BS05	DTP	A	R333 R352 K354 N358 K523	R215 R234 K236 N240 K405
BS06	HEJ	A	Q149 L150 R164 R206 H210 H215 H233 K312 Y315 D319 R366 Y374	Q37 L38 R52 R94 H98 H103 H121 K194 Y197 D201 R248 Y256
BS07	MG	A	Q149 L150 A160 H162	Q37 L38 A48 H50

External links

PDB	RCSB:6dwj, PDBe:6dwj, PDBj:6dwj
PDBsum	6dwj
PubMed	30305425
UniProt	Q9Y3Z3\|SAMH1_HUMAN Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 (Gene Name=SAMHD1)

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