Structure of PDB 6dtd Chain A

Receptor sequence

>6dtdA (length=1053) Species: 28126 (Segatella buccae)

YYELTDKHFWAAFLNLARHNVYTTINHINRRLEIAELKDDGYMMGIKGSW
NEQAKKLDKKVRLRDLIMKHFPFLEAAAYEMTNNNKEQREKEQSEALSLN
NLKNVLFIFLEKLQVLRNYYSHYKYSEESPKPIFETSLLKNMYKVFDANV
RLVKRDYMHHENIDMQRDFTHLNRKKIDSPNFHYHFADKEGNMTIAGLLF
FVSLFLDKKDAIWMQKKLKGFKDGRNLREQMTNEVFCRSRISLPKLKLEN
VQTKDWMQLDMLNELVRCPKSLYERLREKDRESFKVPFDIFEPFKNTLVR
HQDRFPYFVLRYFDLNEIFEQLRFQIDLGTYHFSIYNKRIGDEDEVRHLT
HHLYGFARIQDFAPQNQPEEWRKLVKTSQEPYISKTAPHYHLENEKIGIK
FCSAHNNLFPSLQTDKTCNGRSKFNLGTQFTAEAFLSVHELLPMMFYYLL
LTKDYSRKESADKVEGIIRKEISNIYAIYDAFANNEINSIADLTRRLQNT
NILQGHLPKQMISILKGRQKDMGKEAERKIGEMIDDTQRRLDLLCKQTNQ
KIRIGKRNAGLLKSGKIADWLVNDMMRFQPVQKDQNNIPINNSKANSTEY
RMLQRALALFGSENFRLKAYFNQMNLVGNDNPHPFLAETQWEHQTNILSF
YRNYLEARKKYLKGLKPQNWKQYQHFLILKVQKTNRNTLVTGWKNSFNLP
RGIFTQPIREWFEKHNNSKRIYDQILSFDRVGFVAKAIPLYFAEEYKDNV
QPFYDYPFNIGNRLKPKKRQFLDKKERVELWQKNKELFKNYPSEKKKTDL
AYLDFLSWKKFERELRLIKNQDIVTWLMFKELFNMAGEIHLRDIDTNTAN
EESNNILNRIMPMKLPVKTYETDNKGNILKERPLATFYIEETETKVLKQG
NFKALVKDRRLNGLFSFAETTDLNLEEHPISKLSVDLELIKYQTTRISIF
EMTLGLEKKLIDKYSTLPTDSFRNMLERWLQCKANRPELKNYVNSLIAVR
NAFSHNQYPMYDATLFAEVKKFTLFPKKIELNIAPQLLEIVGKAIKEIEK
SEN

3D structure

• PDB: 6dtd High-Resolution Structure of Cas13b and Biochemical Characterization of RNA Targeting and Cleavage.
• Chain: A
• Resolution: 1.65 Å

Enzymatic activity

• Enzyme Commision number: 3.1.-.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	A	L404 T405 H407 Y409 H452 N455 E456 K457 T478 C479 K484 N486 S498 H500 Y540 L564 G566 H567 L568 P569 K570 Q571 R589 K590 N634 M637 R638 V642 P650 N652 N653 K655 A656 S658 Y661 K741 K744 T749 L750 G753 W754 N756 S757 F758 N759 L760 P761 R762 R791 V792 G793 V795 A796 K797 R838 W842 K846 K857 Y863 L867 K870 K871 E873 R874 R877 L878	L349 T350 H352 Y354 H391 N394 E395 K396 T417 C418 K423 N425 S437 H439 Y479 L503 G505 H506 L507 P508 K509 Q510 R528 K529 N573 M576 R577 V581 P589 N591 N592 K594 A595 S597 Y600 K680 K683 T688 L689 G692 W693 N695 S696 F697 N698 L699 P700 R701 R730 V731 G732 V734 A735 K736 R777 W781 K785 K796 Y802 L806 K809 K810 E812 R813 R816 L817

External links

• PDB: RCSB:6dtd, PDBe:6dtd, PDBj:6dtd
• PDBsum: 6dtd
• PubMed: 30917325
• UniProt: E6K398