Structure of PDB 6dss Chain A

Receptor sequence
>6dssA (length=320) Species: 5833 (Plasmodium falciparum) [Search protein sequence]
GFKVKLEKRRNAINTCLCIGLDPDEKDIENFMKNEKENNYNNIKKNLKEK
YINNVSIKKDILLKAPDNIIREEKSEEFFYFFNHFCFYIINETNKYALTF
KMNFAFYIPYGSVGIDVLKNVFDYLYELNIPTILDMKINDIGNTVKNYRK
FIFEYLKSDSCTVNIYMGTNMLKDICYDEEKNKYYSAFVLVKTTNPDSAI
FQKNLSLDNKQAYVIMAQEALNMSSYLNLEQNNEFIGFVVGANSYDEMNY
IRTYFPNCYILSPGIGAQNGDLHKTLTNGYHKSYEKILINIGRAITKNPY
PQKAAQMYYDQINAILKQNM
3D structure
PDB6dss Re-refinement of Plasmodium falciparum orotidine 5'-monophosphate decarboxylase provides a clearer picture of an important malarial drug target.
ChainA
Resolution2.599 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 4.1.1.23: orotidine-5'-phosphate decarboxylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 U5P A D23 K102 N104 D136 K138 T194 T195 P264 Q269 N291 G293 R294 D22 K101 N103 D135 K137 T193 T194 P263 Q268 N290 G292 R293
BS02 U5P A D141 T145 D140 T144
Gene Ontology
Molecular Function
GO:0004590 orotidine-5'-phosphate decarboxylase activity
GO:0016831 carboxy-lyase activity
Biological Process
GO:0006207 'de novo' pyrimidine nucleobase biosynthetic process
GO:0006221 pyrimidine nucleotide biosynthetic process
GO:0044205 'de novo' UMP biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:6dss, PDBe:6dss, PDBj:6dss
PDBsum6dss
PubMed30279319
UniProtQ8T6J6

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