Structure of PDB 6drx Chain A

Receptor sequence
>6drxA (length=368) Species: 562,9606 [Search protein sequence]
VEEQGNKLHWAALLILMVIIPTIGGNTLVILAVSLEKKLQYATNYFLMSL
AVADLLVGLFVMPIALLTIMFEAMWPLPLVLCPAWLFLDVLFSTASIWHL
CAISVDRYIAIKKPIQANQYNSRATAFIKITVVWLISIGIAIPVPIKGIE
TNPNNITCVLTKERFGDFMLFGSLAAFFTPLAIMIVTYFLTIHALQKKAA
DLEDNWETLNDNLKVIEKADNAAQVKDALTKMRAAFRHGFDILVGQIDDA
LKLANEGKVKEAQAAAEQLKTTRNAYIQKYLQTISNEQRASKVLGIVFFL
FLLMWCPFFITNITLVLCDSCNQTTLQMLLEIFVWIGYVSSGVNPLVYTL
FNKTFRDAFGRYITCNYR
3D structure
PDB6drx Structural determinants of 5-HT2Breceptor activation and biased agonism.
ChainA
Resolution3.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 H8G A W131 L132 D135 V136 S139 F217 A225 W337 F340 W85 L86 D89 V90 S93 F168 A176 W305 F308 PDBbind-CN: -logKd/Ki=9.24,Kd=0.58nM
BS02 CLR A I66 I69 T73 Y394 I20 I23 T27 Y362
Gene Ontology
Molecular Function
GO:0004930 G protein-coupled receptor activity
GO:0004993 G protein-coupled serotonin receptor activity
GO:0005506 iron ion binding
GO:0009055 electron transfer activity
GO:0020037 heme binding
GO:0046872 metal ion binding
Biological Process
GO:0007186 G protein-coupled receptor signaling pathway
GO:0022900 electron transport chain
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0042597 periplasmic space

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Cellular Component
External links
PDB RCSB:6drx, PDBe:6drx, PDBj:6drx
PDBsum6drx
PubMed30127358
UniProtP0ABE7|C562_ECOLX Soluble cytochrome b562 (Gene Name=cybC);
P41595|5HT2B_HUMAN 5-hydroxytryptamine receptor 2B (Gene Name=HTR2B)

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