Structure of PDB 6dqd Chain A

Receptor sequence
>6dqdA (length=306) Species: 9606 (Homo sapiens) [Search protein sequence]
EFVPPPECPVFEPSWEEFTDPLSFIGRIRPLAEKTGICKIRPPKDWQPPF
ACEVKSFRFTPRVQRLNELEAMREAFGFEQAVREYTLQSFGEMADNFKSD
YFNMPVHMVPTELVEKEFWRLVSSIEEDVIVEYGADISSKDFGSGFPVKD
GRRKILPEEEEYALSGWNLNNMPVLEQSVLAHINKVPWLYVGMCFSSFCW
HIEDHWSYSINYLHWGEPKTWYGVPSHAAEQLEEVMRELAPELFESQPDL
LHQLVTIMNPNVLMEHGVPVYRTNQCAGEFVVTFPRAYHSGFNQGYNFAE
AVNFCT
3D structure
PDB6dqd Structural Basis for KDM5A Histone Lysine Demethylase Inhibition by Diverse Compounds.
ChainA
Resolution1.987 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) Y472 H483 E485 H571 A583
Catalytic site (residue number reindexed from 1) Y190 H201 E203 H289 A301
Enzyme Commision number 1.14.11.67: [histone H3]-trimethyl-L-lysine(4) demethylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 H67 A Q75 Y409 A411 D412 W470 Y472 F480 C481 H483 K501 W503 H571 Q64 Y133 A135 D136 W188 Y190 F198 C199 H201 K219 W221 H289
BS02 MN A H483 E485 H571 H201 E203 H289
External links
PDB RCSB:6dqd, PDBe:6dqd, PDBj:6dqd
PDBsum6dqd
PubMed
UniProtP29375|KDM5A_HUMAN Lysine-specific demethylase 5A (Gene Name=KDM5A)

[Back to BioLiP]