Structure of PDB 6dqc Chain A

Receptor sequence
>6dqcA (length=311) Species: 9606 (Homo sapiens) [Search protein sequence]
AEFVPPPECPVFEPSWEEFTDPLSFIGRIRPLAEKTGICKIRPPKDWQPP
FACEVKSFRFTPRVQRLNELEAMTPREAFGFEQAVREYTLQSFGEMADNF
KSDYFNMPVHMVPTELVEKEFWRLVSSIEEDVIVEYGADISSKDFGSGFP
VKDGRRKILPEEEEYALSGWNLNNMPVLEQSVLAHINVMKVPWLYVGMCF
SSFCWHIEDHWSYSINYLHWGEPKTWYGVPSHAAEQLEEVMRELAPELFE
SQPDLLHQLVTIMNPNVLMEHGVPVYRTNQCAGEFVVTFPRAYHSGFNQG
YNFAEAVNFCT
3D structure
PDB6dqc Structural Basis for KDM5A Histone Lysine Demethylase Inhibition by Diverse Compounds.
ChainA
Resolution1.755 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) Y472 H483 E485 H571 A583
Catalytic site (residue number reindexed from 1) Y195 H206 E208 H294 A306
Enzyme Commision number 1.14.11.67: [histone H3]-trimethyl-L-lysine(4) demethylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 H5Y A R73 Y409 Y472 F480 H483 E485 K501 W503 H571 R63 Y136 Y195 F203 H206 E208 K224 W226 H294
BS02 MN A H483 E485 H571 H206 E208 H294
External links
PDB RCSB:6dqc, PDBe:6dqc, PDBj:6dqc
PDBsum6dqc
PubMed
UniProtP29375|KDM5A_HUMAN Lysine-specific demethylase 5A (Gene Name=KDM5A)

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