Structure of PDB 6dq5 Chain A

Receptor sequence
>6dq5A (length=298) Species: 9606 (Homo sapiens) [Search protein sequence]
EFVPPPECPVFEPSWEEFTDPLSFIGRIRPLAEKTGICKIRPPKDWQPPF
ACEVKSFRFTPRVQRLNELEAMTVREYTLQSFGEMADNFKSDYFNMPVHM
VPTELVEKEFWRLVSSIEEDVIVEYGADISSKDFGSGFPVKDGRRKILPE
EEEYALSGWNLNNMPVLEQSVLAHINVKVPWLYVGMCFSSFCWHIEDHWS
YSINYLHWGEPKTWYGVPSHAAEQLEEVMRELAPELFESQPDLLHQLVTI
MNPNVLMEHGVPVYRTNQCAGEFVVTFPRAYHSGFNQGYNFAEAVNFC
3D structure
PDB6dq5 Structure-Based Engineering of Irreversible Inhibitors against Histone Lysine Demethylase KDM5A.
ChainA
Resolution1.89 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) Y472 H483 E485 H571 A583
Catalytic site (residue number reindexed from 1) Y183 H194 E196 H282 A294
Enzyme Commision number 1.14.11.67: [histone H3]-trimethyl-L-lysine(4) demethylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 H6G A R73 Y409 Y472 F480 C481 H483 E485 K501 R62 Y125 Y183 F191 C192 H194 E196 K212 MOAD: Kd=6.4uM
PDBbind-CN: -logKd/Ki=5.19,Kd=6.4uM
BindingDB: Kd=6000nM,IC50=71000nM
BS02 MN A H483 E485 H194 E196
External links
PDB RCSB:6dq5, PDBe:6dq5, PDBj:6dq5
PDBsum6dq5
PubMed30392349
UniProtP29375|KDM5A_HUMAN Lysine-specific demethylase 5A (Gene Name=KDM5A)

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