Structure of PDB 6dq4 Chain A

Receptor sequence
>6dq4A (length=312) Species: 9606 (Homo sapiens) [Search protein sequence]
AEFVPPPECPVFEPSWEEFTDPLSFIGRIRPLAEKTGICKIRPPKDWQPP
FACEVKSFRFTPRVQRLNELEAMTRPREAFGFEQAVREYTLQSFGEMADN
FKSDYFNMPVHMVPTELVEKEFWRLVSSIEEDVIVEYGADISSKDFGSGF
PVKDGRRKILPEEEEYALSGWNLNNMPVLEQSVLAHINVMKVPWLYVGMC
FSSFCWHIEDHWSYSINYLHWGEPKTWYGVPSHAAEQLEEVMRELAPELF
ESQPDLLHQLVTIMNPNVLMEHGVPVYRTNQCAGEFVVTFPRAYHSGFNQ
GYNFAEAVNFCT
3D structure
PDB6dq4 Structure-Based Engineering of Irreversible Inhibitors against Histone Lysine Demethylase KDM5A.
ChainA
Resolution1.392 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) Y472 H483 E485 H571 A583
Catalytic site (residue number reindexed from 1) Y196 H207 E209 H295 A307
Enzyme Commision number 1.14.11.67: [histone H3]-trimethyl-L-lysine(4) demethylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 K0I A R73 Y409 A411 D412 Y472 F480 H483 E485 K501 R63 Y137 A139 D140 Y196 F204 H207 E209 K225 MOAD: Kd=12uM
PDBbind-CN: -logKd/Ki=4.92,Kd=12uM
BindingDB: IC50=110000nM,Kd=12000nM
BS02 MN A H483 E485 H207 E209
External links
PDB RCSB:6dq4, PDBe:6dq4, PDBj:6dq4
PDBsum6dq4
PubMed30392349
UniProtP29375|KDM5A_HUMAN Lysine-specific demethylase 5A (Gene Name=KDM5A)

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