Structure of PDB 6dp4 Chain A

Receptor sequence
>6dp4A (length=136) Species: 272558 (Halalkalibacterium halodurans C-125) [Search protein sequence]
EEIIWESLSVDVGSQGNPGIVEYKGVDTKTGEVLFEREPIPIGTNNMGEF
LAIVHGLRYLKERNSRKPIYSDSQTAIKWVKDKKAKSTLVRNEETALIWK
LVDEAEEWLNTHTYETPILKWQTDKWGEIKADYGRK
3D structure
PDB6dp4 Cation trafficking propels RNA hydrolysis.
ChainA
Resolution1.374 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.26.4: ribonuclease H.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna A N105 E109 D132 Q134 K180 T183 N45 E49 D72 Q74 K120 T123
BS02 rna A D71 V72 G73 S74 G76 N105 R195 K196 D11 V12 G13 S14 G16 N45 R135 K136
BS03 dna A N77 T104 N105 N106 K138 W139 K146 S147 T148 N17 T44 N45 N46 K78 W79 K86 S87 T88
BS04 MG A D71 D192 D11 D132
BS05 MG A D71 E109 D132 D11 E49 D72
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0004523 RNA-DNA hybrid ribonuclease activity

View graph for
Molecular Function
External links
PDB RCSB:6dp4, PDBe:6dp4, PDBj:6dp4
PDBsum6dp4
PubMed30076410
UniProtQ9KEI9|RNH1_HALH5 Ribonuclease H (Gene Name=rnhA)

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