Structure of PDB 6doh Chain A

Receptor sequence
>6dohA (length=133) Species: 272558 (Halalkalibacterium halodurans C-125) [Search protein sequence]
EEIIWESLSVDVGSQGNPGIVEYKGVDTKTGEVLFEREPIPIGTNNMGEF
LAIVHGLRYLKERNSRKPIYSDSQTAIKWVKDKKAKSTLVRNEETALIWK
LVDEAEEWLNTHTYETPILKWQTDKWGEIKADY
3D structure
PDB6doh Cation trafficking propels RNA hydrolysis.
ChainA
Resolution1.363 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.26.4: ribonuclease H.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna A E109 D132 Q134 K180 T183 E49 D72 Q74 K120 T123
BS02 rna A V72 G73 S74 G76 N77 N105 V12 G13 S14 G16 N17 N45
BS03 dna A N77 P78 T104 N105 N106 T135 K138 W139 K146 S147 T148 N17 P18 T44 N45 N46 T75 K78 W79 K86 S87 T88
BS04 CA A D71 D192 D11 D132
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0004523 RNA-DNA hybrid ribonuclease activity

View graph for
Molecular Function
External links
PDB RCSB:6doh, PDBe:6doh, PDBj:6doh
PDBsum6doh
PubMed30076410
UniProtQ9KEI9|RNH1_HALH5 Ribonuclease H (Gene Name=rnhA)

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