Structure of PDB 6dio Chain A

Receptor sequence
>6dioA (length=376) Species: 80866 (Delftia acidovorans) [Search protein sequence]
VADSRLPNFRALTPAQRRDFLADACGLSDAERALLAAPGALPLALADGMI
ENVFGSFELPLGVAGNFRVNGRDVLVPMAVEEPSVVAAASYMAKLAREDG
GFQTSSTLPLMRAQVQVLGVTDPHGARLAVLQARAQIIERANSRDKVLIG
LGGGCKDIEVHVFPDTPRGPMLVVHLIVDVRDAMGANTVNTMAESVAPLV
EKITGGSVRLRILSNLADLRLARARVRLTPQTLATQDRSGEEIIEGVLDA
YTFAAIDPYRAATHNKGIMNGIDPVIVATGNDWRAVEAGAHAYASRSGSY
TSLTRWEKDAGGALVGSIELPMPVGLVGGATKTHPLARLALKIMDLQSAQ
QLGEIAAAVGLAQNLGALRALATEGI
3D structure
PDB6dio New Crystallographic Snapshots of Large Domain Movements in Bacterial 3-Hydroxy-3-methylglutaryl Coenzyme A Reductase.
ChainA
Resolution2.14 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.1.1.88: hydroxymethylglutaryl-CoA reductase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NAD A D146 V148 L152 R182 D183 A184 M185 G186 A187 N188 T189 L214 N216 D283 V328 G329 G330 D145 V147 L151 R181 D182 A183 M184 G185 A186 N187 T188 L213 N215 D282 V327 G328 G329
BS02 NAD A E83 K267 E82 K266
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0004420 hydroxymethylglutaryl-CoA reductase (NADPH) activity
GO:0016491 oxidoreductase activity
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0140643 hydroxymethylglutaryl-CoA reductase (NADH) activity
Biological Process
GO:0015936 coenzyme A metabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:6dio, PDBe:6dio, PDBj:6dio
PDBsum6dio
PubMed30199631
UniProtA9BQX8

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