Structure of PDB 6dha Chain A

Receptor sequence
>6dhaA (length=255) Species: 9606 (Homo sapiens) [Search protein sequence]
ESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLM
MGEDEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYG
VHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFA
VKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQALELQL
KLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIKKTETDMSLHPLLQE
IYKDL
3D structure
PDB6dha Structural Basis of Altered Potency and Efficacy Displayed by a Major in Vivo Metabolite of the Antidiabetic PPAR gamma Drug Pioglitazone.
ChainA
Resolution1.88 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GFV A I281 F282 G284 C285 Q286 S289 H323 I341 M348 M364 H449 Y473 I60 F61 G63 C64 Q65 S68 H102 I120 M127 M143 H228 Y252 MOAD: Kd=708nM
PDBbind-CN: -logKd/Ki=5.68,IC50=2.1uM
BindingDB: EC50=1300nM,Ki=1200nM,Kd=708nM,IC50=13000nM
BS02 KNA A L228 R288 M329 L330 L333 E343 L22 R67 M108 L109 L112 E122
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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Biological Process
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Cellular Component
External links
PDB RCSB:6dha, PDBe:6dha, PDBj:6dha
PDBsum6dha
PubMed30676741
UniProtP37231|PPARG_HUMAN Peroxisome proliferator-activated receptor gamma (Gene Name=PPARG)

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