Structure of PDB 6df8 Chain A

Receptor sequence

>6df8A (length=118) Species: 9606 (Homo sapiens) [Search protein sequence]

DHYELIVDGRVYYICIVCKRSYVCLTSLRRHFNIHSWEKKYPCRYCEKVF
PLAEYRTKHEIHHTGERRYQCLACGKSFINYQFMSSHIKSVHSQDPSGDS
KLYRLHPCRSLQIRQYAY

3D structure

PDB

6df8 A conformational switch in the zinc finger protein Kaiso mediates differential readout of specific and methylated DNA sequences.

Chain

Resolution

2.536 Å

3D
structure

Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	dna	A	R501 Y503 V504 C505 S508 R511 E535 Y536 F564 R595 A598	R20 Y22 V23 C24 S27 R30 E54 Y55 F83 R114 A117
BS02	dna	A	K520 A534 E535 T538 R549 Y550 Y562 Q563 S578 Y584 L586 R595 Y597	K39 A53 E54 T57 R68 Y69 Y81 Q82 S97 Y103 L105 R114 Y116
BS03	ZN	A	C496 C499 H512 H516	C15 C18 H31 H35
BS04	ZN	A	C524 C527 H540 H544	C43 C46 H59 H63
BS05	ZN	A	C552 C555 H568 H573	C71 C74 H87 H92

External links

PDB	RCSB:6df8, PDBe:6df8, PDBj:6df8
PDBsum	6df8
PubMed	32352758
UniProt	Q86T24\|KAISO_HUMAN Transcriptional regulator Kaiso (Gene Name=ZBTB33)