Structure of PDB 6df5 Chain A

Receptor sequence

>6df5A (length=116) Species: 9606 (Homo sapiens) [Search protein sequence]

DHYELIVDGRVYYICIVCKRSYVCLTSLRRHFNIHSWEKKYPCRYCEKVF
PLAEYRTKHEIHHTGERRYQCLACGKSFINYQFMSSHIKSVHSQDPSGDS
KLYRLHPCRSLQIRQY

3D structure

PDB

6df5 A conformational switch in the zinc finger protein Kaiso mediates differential readout of specific and methylated DNA sequences.

Chain

Resolution

1.819 Å

3D
structure

Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	dna	A	Y503 V504 S508 R511 Y536 Q563 F564 R595 Q596 Y597	Y22 V23 S27 R30 Y55 Q82 F83 R114 Q115 Y116
BS02	dna	A	A534 T538 R549 Y550 Y562 Q563 S578 Y584 L586 R595	A53 T57 R68 Y69 Y81 Q82 S97 Y103 L105 R114
BS03	ZN	A	C496 C499 H512 H516	C15 C18 H31 H35
BS04	ZN	A	C524 C527 H540 H544	C43 C46 H59 H63
BS05	ZN	A	C552 C555 H568 H573	C71 C74 H87 H92

External links

PDB	RCSB:6df5, PDBe:6df5, PDBj:6df5
PDBsum	6df5
PubMed	32352758
UniProt	Q86T24\|KAISO_HUMAN Transcriptional regulator Kaiso (Gene Name=ZBTB33)