Structure of PDB 6dbm Chain A

Receptor sequence
>6dbmA (length=274) Species: 9606 (Homo sapiens) [Search protein sequence]
PTVFHKRYLKKIRDLGEGHFGKVSLYCYEMVAVKALKQHRSGWKQEIDIL
RTLYHEHIIKYKGCCEDAGAASLQLVMEYVPLGSLRDYLPRHSIGLAQLL
LFAQQICEGMAYLHSQHYIHRDLAARNVLLDNDRLVKIGDFGLAKAVPEG
HEYYRDGDSPVFWYAPECLKEYKFYYASDVWSFGVTLYELLTHCDSSQSP
PTKFLELIGIAQGQMTVLRLTELLERGERLPRPDKCPAEVYHLMKNCWET
EASFRPTFENLIPILKTVHEKYQG
3D structure
PDB6dbm Dual Inhibition of TYK2 and JAK1 for the Treatment of Autoimmune Diseases: Discovery of (( S)-2,2-Difluorocyclopropyl)((1 R,5 S)-3-(2-((1-methyl-1 H-pyrazol-4-yl)amino)pyrimidin-4-yl)-3,8-diazabicyclo[3.2.1]octan-8-yl)methanone (PF-06700841).
ChainA
Resolution2.368 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D1023 A1025 R1027 N1028 D1041 P1064
Catalytic site (residue number reindexed from 1) D122 A124 R126 N127 D140 P160
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 G4J A L903 G904 E905 G906 V911 K930 I960 Y980 V981 G984 L1030 G1040 D1041 L15 G16 E17 G18 V23 K34 I59 Y79 V80 G83 L129 G139 D140 MOAD: ic50=23nM
BindingDB: IC50=23.0nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:6dbm, PDBe:6dbm, PDBj:6dbm
PDBsum6dbm
PubMed30113844
UniProtP29597|TYK2_HUMAN Non-receptor tyrosine-protein kinase TYK2 (Gene Name=TYK2)

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