Structure of PDB 6d94 Chain A

Receptor sequence
>6d94A (length=271) Species: 9606 (Homo sapiens) [Search protein sequence]
ESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLM
MGEDKIKFKHITPLQEQSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGF
VNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSL
RKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPI
EDIQDNLLQALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVI
KKTETDMSLHPLLQEIYKDLY
3D structure
PDB6d94 A structural mechanism of nuclear receptor biased agonism.
ChainA
Resolution1.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A K301 N312 V315 K319 P467 L468 E471 K95 N106 V109 K113 P261 L262 E265
BS02 EDK A F282 G284 C285 Q286 S289 H323 L330 I341 M348 F363 M364 H449 Y473 F76 G78 C79 Q80 S83 H117 L124 I135 M142 F157 M158 H243 Y267 BindingDB: Ki=1.4nM,EC50=6.2nM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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External links
PDB RCSB:6d94, PDBe:6d94, PDBj:6d94
PDBsum6d94
PubMed36469765
UniProtP37231|PPARG_HUMAN Peroxisome proliferator-activated receptor gamma (Gene Name=PPARG)

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