Structure of PDB 6d6v Chain A

Receptor sequence

>6d6vA (length=980) Species: 5911 (Tetrahymena thermophila)

QMLTRKEDLLTVLKQISALKYVSNLYEFLLATEKIVQTSELDTQFQEFLT
TTIIASEQNLVENYKQKYNQPNFSQLTIKQVIDDSIILLGNKQNYVQQIG
TTTIGFYVEYENINLSRQTLYSSNFRNLLNIFGEEDFKYFLIDFLVFTKV
EQNGYLQVAGVCLNQYFSVQKQENQYIYPEIQRSQIFYCNHMGREPGVFK
SSFFNYQSKNFSCQEERDLFLEFTEKIVQNFHNINFNYLLKKFCKLPENY
QSLKSQVKQIVQSENKANQQSCENLFNSLYDTEISYKQITNFLRQIIQNC
VPNQLLGKKNFKVFLEKLYEFVQMKRFENQKVLDYICFMDVFDVEWFVDL
KNQKFTQKRKYISDKRKILGDLIVFIINKIVIPVLRYNFYITEKHKEGSQ
IFYYRKPIWKLVSKLTIVKLEEFQKYPQGKLRIIPKKGSFRPIMTFLRKD
KQKNIKLNLNQILMDSQLVFRNLKDMLGQKIGYSVFDNKQISEKFAQFIE
KWKNKGRPQLYYVTLDIKKCYDSIDQMKLLNFFNQSDLIQDTYFINKYLL
FQRNKRPLLQIQNFPYYFNLKERQIAYSLYDDDDQILQKGFKEIQSDDRP
FIVINQDKPRCITKDIIHNHLKHISQYNVISFNKVKFRQKRGIPQGLNIS
GVLCSFYFGKLEEEYTQFLKNAEQVNGSINLLMRLTDDYLFISDSQQNAL
NLIVQLQNCANNNGFMFNDQKITTNFQFPQEDYNLEHFKISVQNECQWIG
KSIDMNTLEIKSIQKQTQQEINQTINVAISIKNLKSQLKNKLRSLFLNQL
IDYFNPNINSFEGLCRQLYHHSKATVMKFYPFMTKLFQIDLKKSKQYSVQ
YGKENTNENFLKDILYYTVEDVCKILCYLQFEDEINSNIKEIFKNLYSWI
MWDIIVSYLKKKKQFKGYLNKLLQKIRKSRFFYLKEGCKSLQLILSQQKY
QLNKKELEAIEFIDLNNLIQDIKTLIPKIS

3D structure

• PDB: 6d6v Structure of Telomerase with Telomeric DNA.
• Chain: A
• Resolution: 4.8 Å

Enzymatic activity

• Enzyme Commision number: 2.7.7.49: RNA-directed DNA polymerase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	A	F178 Q181 N217 Q218 Y231 H234 M235 G236 R237 E238 F242 K243 S244 N324 Y325 L327 K328 K332 L333 Y337 K341 K374 R413 L420 C424 Q444 K445 R446 K447 I449 S450 R453 R473 K497 K501 K532 I545 R550 R573 D589 N590 R655 N691 F696 N697 K699 K762 N776 I909 K910 K913 K917 N918 R921 F924 L969 K971 K973 Q974 Q978 D991 Y994 Y995 E998 K1038 K1041 Q1042 K1044 K1053 R1055 K1056 S1057 F1059 F1060 K1063	F167 Q170 N174 Q175 Y188 H191 M192 G193 R194 E195 F199 K200 S201 N237 Y238 L240 K241 K245 L246 Y250 K254 K287 R326 L333 C337 Q357 K358 R359 K360 I362 S363 R366 R386 K410 K414 K430 I443 R448 R471 D487 N488 R553 N563 F568 N569 K571 K634 N648 I781 K782 K785 K789 N790 R793 F796 L841 K843 K845 Q846 Q850 D863 Y866 Y867 E870 K910 K913 Q914 K916 K925 R927 K928 S929 F931 F932 K935
BS02	dna	A	Q228 F414 H482 I545 K555 Y623 Q773 D815 D816 I877 G878 T902 N904 K919 S922 F924 L925 F960	Q185 F327 H395 I443 K453 Y521 Q645 D687 D688 I749 G750 T774 N776 K791 S794 F796 L797 F832

Gene Ontology

Molecular Function

• GO:0003677 DNA binding
• GO:0003720 telomerase activity
• GO:0003723 RNA binding
• GO:0003964 RNA-directed DNA polymerase activity
• GO:0042162 telomeric DNA binding
• GO:0046872 metal ion binding
• GO:0070034 telomerase RNA binding

Biological Process

• GO:0007004 telomere maintenance via telomerase

Cellular Component

• GO:0000333 telomerase catalytic core complex
• GO:0000781 chromosome, telomeric region
• GO:0005634 nucleus
• GO:0005694 chromosome
• GO:0005697 telomerase holoenzyme complex
• GO:0043231 intracellular membrane-bounded organelle

External links

• PDB: RCSB:6d6v, PDBe:6d6v, PDBj:6d6v
• PDBsum: 6d6v
• PubMed: 29775593
• UniProt: O77448|TERT_TETTS Telomerase reverse transcriptase (Gene Name=TERT)