Structure of PDB 6d40 Chain A

Receptor sequence
>6d40A (length=246) Species: 9606 (Homo sapiens) [Search protein sequence]
PSFDCGKPQVEPKKCPVVGGCVAHPHSWPWQVSLRTRFGMHFCGGTLISP
EWVLTAAHCLEKSPRPSSYKVILGAHQEVNLEPHVQEIEVSRLFLEPTRK
DIALLKLSSPAVITDKVIPACLPSPNYVVADRTECFITGWGETQGTFGAG
LLKEAQLPVIENKVCNRYEFLNGRVQSTELCAGHLAGGTDSCQGDSGGPL
VCFEKDKYILQGVTSWGLGCARPNKPGVYVRVSRFVTWIEGVMRNN
3D structure
PDB6d40 Highly Potent and Selective Plasmin Inhibitors Based on the Sunflower Trypsin Inhibitor-1 Scaffold Attenuate Fibrinolysis in Plasma.
ChainA
Resolution1.43 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H603 D646 Q738 G739 D740 S741
Catalytic site (residue number reindexed from 1) H58 D101 Q193 G194 D195 S196
Enzyme Commision number 3.4.21.7: plasmin.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A F587 H603 D646 R719 S736 C737 Q738 G739 S741 S760 W761 G762 L763 F42 H58 D101 R174 S191 C192 Q193 G194 S196 S215 W216 G217 L218
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:6d40, PDBe:6d40, PDBj:6d40
PDBsum6d40
PubMed30520638
UniProtP00747|PLMN_HUMAN Plasminogen (Gene Name=PLG)

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