Structure of PDB 6d3s Chain A

Receptor sequence
>6d3sA (length=1127) Species: 9031 (Gallus gallus) [Search protein sequence]
SADSADNLSEKLEREWDRELATSKKKPKLINALRRCFFWKFMFYGILLYL
GEVTKSVQPLLLGRIIASYDPDNSSERSIAYYLGIGLCLLFLVRTLLIHP
SIFGLHHIGMQIRIALFSLIYKKTLKLSSKVLDKISTGQLVSLLSNNLNK
FDEGLALAHFVWIAPLQVALLMGLLWDMLQASAFAGLAFLIVMAFFQAWL
GQMMMKYRDKRAGKINERLVITSEIIENIQSVKAYCWEDAMEKMIESLRE
TELKLTRKAAYVRYFNSSAFFFSGFFVVFLAVVPYAVTKGIILRKIFTTI
SFCIVLRMTVTRQFPGSVQTWYDSIGAINKIQDFLLKEEYKALEYNLTTT
GVEVDKVTAFWDEHASPVLQDINFKIEKGELLAVSGSTGSGKTSLLMLIM
GELEPSEGKIKHSGRISFSPQVSWIMPGTIKENIIFGVSYDEYRYKSVIQ
ACQLEEDILKFPDKDYTVLGEGGIILSGGQRARISLARAVYKDADLYLMD
SPFGYLDIFTEKEIFESCVCKLMANKTRILVTSKLEHLKIADKILILHEG
SCYFYGTFSELQGQRPDFSSELMGFDSFDQFSAERRNSIITETLRRFSFW
NTYFRYITIHKSLIFVLILCVTIFLLEVAASLVLLLFLYYMIYIYVGIAD
TLLAMGIFRGLPLVHTLITVSKTLHQKMVHAVLYAPMSTFNSLKAGGILN
RFSKDTAILDDLLPLTVFDLIQLILIVIGAITVVSILQPYIFLASVPVIA
AFIVLRAYFLHTSQQLKQLESEARSPIFTHLVTSLKGLWTLRAFGRQPYF
ETLFHKALNLHTANWFLYLSTLRWFQMRIEMIFVVFFSAVAFISIITTGD
GPGRVGIILTLAMNIMGTLQWAVNSSIDVDSLMRSVSRIFKFIDGGQMTV
TDLTARYTEGGTAVLENISFSISSGQTVGLLGRTGSGKSTLLFAFLRLLN
TEGDIQIDGVSWNTVSLQQWRKAFGVIPQKVFIFSGTFRKNLDPYGQWND
EEIWKVAEEVGLKSVIEQFPGQLDFVLVDGGCVLSHGHKQLMCLARSVLS
KAKILLLDEPSAHLDPITSQVIRKTLKHAFADCTVVLSESRLEAILECQR
FLVIEDNKMRQYESIQKLLSEKSSLRQ
3D structure
PDB6d3s Cryo-EM Visualization of an Active High Open Probability CFTR Anion Channel.
ChainA
Resolution6.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 5.6.1.6: channel-conductance-controlling ATPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ATP A W402 G462 G464 K465 T466 S467 W361 G389 G391 K392 T393 S394
BS02 ATP A T1248 G1249 G1251 K1252 S1253 T934 G935 G937 K938 S939
Gene Ontology
Molecular Function
GO:0005254 chloride channel activity
GO:0005260 intracellularly ATP-gated chloride channel activity
GO:0005524 ATP binding
GO:0015106 bicarbonate transmembrane transporter activity
GO:0015108 chloride transmembrane transporter activity
GO:0016853 isomerase activity
GO:0016887 ATP hydrolysis activity
GO:0140359 ABC-type transporter activity
Biological Process
GO:0006811 monoatomic ion transport
GO:0006821 chloride transport
GO:0015701 bicarbonate transport
GO:0034220 monoatomic ion transmembrane transport
GO:0055085 transmembrane transport
GO:1902476 chloride transmembrane transport
Cellular Component
GO:0005768 endosome
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016324 apical plasma membrane
GO:0031901 early endosome membrane
GO:0034707 chloride channel complex
GO:0055038 recycling endosome membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6d3s, PDBe:6d3s, PDBj:6d3s
PDBsum6d3s
PubMed30281975
UniProtA0M8U4

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