Structure of PDB 6d3k Chain A

Receptor sequence
>6d3kA (length=258) Species: 9606 (Homo sapiens) [Search protein sequence]
KYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKA
EREVKALAKLDHVNIVHYNGCWDGFDYDPRSKTKCLFIQMEFCDKGTLEQ
WIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTK
QVKIGDFGLVTSLKTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCD
TAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTL
TVWKKSPE
3D structure
PDB6d3k Structural Basis of Protein Kinase R Autophosphorylation.
ChainA
Resolution2.6 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) D414 K416 S418 N419 D432 T451
Catalytic site (residue number reindexed from 1) D138 K140 S142 N143 D156 T165
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP A V281 V294 K296 C369 T373 S418 F421 D432 V26 V39 K41 C93 T97 S142 F145 D156
BS02 MG A N419 D432 N143 D156
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:6d3k, PDBe:6d3k, PDBj:6d3k
PDBsum6d3k
PubMed31246429
UniProtP19525|E2AK2_HUMAN Interferon-induced, double-stranded RNA-activated protein kinase (Gene Name=EIF2AK2)

[Back to BioLiP]