Structure of PDB 6d3g Chain A

Receptor sequence
>6d3gA (length=279) Species: 546 (Citrobacter freundii) [Search protein sequence]
SAQSPLLKEQIETIVTGKKATVGVAVWGPDDLEPLLLNPFEKFPMQSVFK
LHLAMLVLHQVDQGKLDLNQSVTVNRAAVLQNTWSPMMKDHQGDEFTVAV
QQLLQYSVSHSDNVACDLLFELVGGPQALHAYIQSLGVKEAAVVANEAQM
HADDQVQYQNWTSMKAAAQVLQKFEQKKQLSETSQALLWKWMVETTTGPQ
RLKGLLPAGTIVAHKTGTSGVRAGKTAATNDAGVIMLPDGRPLLVAVFVK
DSAESERTNEAIIAQVAQAAYQFELKKLS
3D structure
PDB6d3g Structural Insights into the Inhibition of the Extended-Spectrum beta-Lactamase PER-2 by Avibactam.
ChainA
Resolution2.398 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) S70 K73 S130 E166 K234 T237
Catalytic site (residue number reindexed from 1) S47 K50 S111 E147 K215 T218
Enzyme Commision number 3.5.2.6: beta-lactamase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NXL A S70 W105 S130 N132 T235 G236 T237 S47 W84 S111 N113 T216 G217 T218 PDBbind-CN: -logKd/Ki=4.70,Ki=20uM
Gene Ontology
Molecular Function
GO:0008800 beta-lactamase activity
Biological Process
GO:0017001 antibiotic catabolic process
GO:0030655 beta-lactam antibiotic catabolic process
GO:0046677 response to antibiotic

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Molecular Function
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Biological Process
External links
PDB RCSB:6d3g, PDBe:6d3g, PDBj:6d3g
PDBsum6d3g
PubMed31235626
UniProtA2RP81

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