Structure of PDB 6d1y Chain A

Receptor sequence
>6d1yA (length=300) Species: 9606 (Homo sapiens) [Search protein sequence]
GKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECH
NLLDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGR
PLLMVFEYMRHGDLNRFLRSHGPDAKLGPLGLGQLLAVASQVAAGMVYLA
GLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRTMLPIRWMPP
ESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGREL
ERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG
3D structure
PDB6d1y Discovery of Allosteric, Potent, Subtype Selective, and Peripherally Restricted TrkA Kinase Inhibitors.
ChainA
Resolution1.93 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D650 R654 N655 D668
Catalytic site (residue number reindexed from 1) D158 R162 N163 D176
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FQJ A S484 G485 L486 E560 F646 H648 D668 G670 S4 G5 L6 E77 F154 H156 D176 G178 BindingDB: IC50=3300nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation
GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway
Cellular Component
GO:0016020 membrane

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Molecular Function
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Cellular Component
External links
PDB RCSB:6d1y, PDBe:6d1y, PDBj:6d1y
PDBsum6d1y
PubMed29672039
UniProtP04629|NTRK1_HUMAN High affinity nerve growth factor receptor (Gene Name=NTRK1)

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