Structure of PDB 6d1u Chain A

Receptor sequence

>6d1uA (length=553) Species: 9606,83333 [Search protein sequence]

EEGKLVIWINGDKGYNGLAEVGKKFEKDTGIKVTVEHPDKLEEKFPQVAA
TGDGPDIIFWAHDRFGGYAQSGLLAEITPDKAFQDKLYPFTWDAVRYNGK
LIAYPIAVEALSLIYNKDLLPNPPKTWEEIPALDKELKAKGKSALMFNLQ
EPYFTWPLIAADGGYAFKYENGKYDIKDVGVDNAGAKAGLTFLVDLIKNK
HMNADTDYSIAEAAFNKGETAMTINGPWAWSNIDTSKVNYGVTVLPTFKG
QPSKPFVGVLSAGINAASPNKELAKEFLENYLLTDEGLEAVNKDKPLGAV
ALKSYEEELAKDPRIAATMENAQKGEIMPNIPQMSAFWYAVRTAVINAAS
GRQTVDEALKDAQTNAAAEFTTACQEANYGALLRELCLTQFQVDMEAVGE
TLWCDWGRTIRSYRELADCTWHMAEKLGCFWPNAEVDRFFLAVHGRYFRS
CPISGRAVGVTRNKIMTAQYECYQKIMQDPIQQAEGVYCNRTWDGWLCWN
DVAAGTESMQLCPDYFQDFDPSEKVTKICDQDGNWFRHPASNRTWTNYTQ
CNV

3D structure

PDB

6d1u Structure-function analyses reveal a triple beta-turn receptor-bound conformation of adrenomedullin 2/intermedin and enable peptide antagonist design.

Chain

Resolution

2.05 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	peptide	A	Y343 A372 F374 W1084 D2070 G2071 W2072 F2092 Q2093 H2114 A2116 S2117 R2119 W2121 T2122 Y2124	Y339 A368 F370 W431 D494 G495 W496 F516 Q517 H538 A540 S541 R543 W545 T546 Y548
BS02	GLC	A	D16 K17 E113 Y157 W232	D12 K13 E109 Y153 W228
BS03	GLC	A	W64 D67 R68 E155 P156 Y157 W342	W60 D63 R64 E151 P152 Y153 W338

Gene Ontology

	Molecular Function
GO:0004930	G protein-coupled receptor activity
GO:0015026	coreceptor activity
GO:0015144	carbohydrate transmembrane transporter activity

	Biological Process
GO:0006886	intracellular protein transport
GO:0007186	G protein-coupled receptor signaling pathway
GO:0008277	regulation of G protein-coupled receptor signaling pathway
GO:0008643	carbohydrate transport
GO:0055085	transmembrane transport

	Cellular Component
GO:0016020	membrane

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External links

PDB	RCSB:6d1u, PDBe:6d1u, PDBj:6d1u
PDBsum	6d1u
PubMed	30139742
UniProt	O60894\|RAMP1_HUMAN Receptor activity-modifying protein 1 (Gene Name=RAMP1); P0AEX9\|MALE_ECOLI Maltose/maltodextrin-binding periplasmic protein (Gene Name=malE); Q16602\|CALRL_HUMAN Calcitonin gene-related peptide type 1 receptor (Gene Name=CALCRL)

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