Structure of PDB 6d19 Chain A

Receptor sequence
>6d19A (length=269) Species: 573 (Klebsiella pneumoniae) [Search protein sequence]
MLTNLVAEPFAKLEQDFGGSIGVYAMDTGSGATVSYRAEERFPLCSSFKG
FLAAAVLARSQQQAGLLDTPIRYGKNALVPWSPISEKYLTTGMTVAELSA
AAVQYSDNAAANLLLKELGGPAGLTAFMRSIGDTTFRLDRWELELNSAIP
GDARDTSSPRAVTESLQKLTLGSALAAPQRQQFVDWLKGNTTGNHRIRAA
VPADWAVGDKTGTCGVYGTANDYAVVWPTGRAPIVLAVYTRAPNKDDKHS
EAVIAAAARLALEGLGVNG
3D structure
PDB6d19 Heteroaryl Phosphonates as Noncovalent Inhibitors of Both Serine- and Metallocarbapenemases.
ChainA
Resolution1.45 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) S70 K73 S130 E166 K234 T237
Catalytic site (residue number reindexed from 1) S46 K49 S106 E142 K210 T213
Enzyme Commision number 3.5.2.6: beta-lactamase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 YKG A S70 W105 S130 T235 G236 T237 S46 W81 S106 T211 G212 T213 MOAD: Ki=0.246uM
PDBbind-CN: -logKd/Ki=6.61,Ki=0.246uM
BS02 YKG A R83 G147 A150 F151 R59 G123 A126 F127 MOAD: Ki=0.246uM
PDBbind-CN: -logKd/Ki=6.61,Ki=0.246uM
Gene Ontology
Molecular Function
GO:0008800 beta-lactamase activity
GO:0016787 hydrolase activity
Biological Process
GO:0017001 antibiotic catabolic process
GO:0030655 beta-lactam antibiotic catabolic process
GO:0046677 response to antibiotic

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:6d19, PDBe:6d19, PDBj:6d19
PDBsum6d19
PubMed31483651
UniProtQ9F663|BLKPC_KLEPN Carbapenem-hydrolyzing beta-lactamase KPC (Gene Name=bla)

[Back to BioLiP]