Structure of PDB 6d06 Chain A

Receptor sequence

>6d06A (length=384) Species: 9606 (Homo sapiens)

LHLPQVLADAVSRLVLGKFGDLTDNFSSPHARRKVLAGVVMTTGTDVKDA
KVISVSTGTKCINGEYMSDRGLALNDCHAEIISRRSLLRFLYTQLELYLN
NKDDQKRSIFQKSERGGFRLKENVQFHLYISTSPCGDARIFSPHEPILEE
PADRHPNRKARGQLRTKIESGYGTIPVRSNASIQTWDGVLQGERLLTMSC
SDKIARWNVVGIQGSLLSIFVEPIYFSSIILGSLYHGDHLSRAMYQRISN
IEDLPPLYTLNKPLLSGISNAEARQPGKAPNFSVNWTVGDSAIEVINATT
GKDELGRASRLCKHALYCRWMRVHGKVPSHLLRSKITKPNVYHESKLAAK
EYQAAKARLFTAFIKAGLGAWVEKPTEQDQFSLT

3D structure

• PDB: 6d06 A Bump-Hole Approach for Directed RNA Editing.
• Chain: A
• Resolution: 2.55 Å

Enzymatic activity

• Enzyme Commision number: 3.5.4.37: double-stranded RNA adenine deaminase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	A	T375 K376 H394 E396 C451 R455 H460 H471 N473 R474 K475 S486 G487 Y488 C516	T59 K60 H78 E80 C135 R139 H144 H155 N157 R158 K159 S170 G171 Y172 C200
BS02	rna	A	R348 I456 F457 R470 H471 R474 A476 R477 R481 Y488 I491 P492 S495 R510 K594	R32 I140 F141 R154 H155 R158 A160 R161 R165 Y172 I175 P176 S179 R194 K278
BS03	IHP	A	I397 R401 K519 R522 G530 S531 K629 Y658 K662 Y668 K672 E689 K690	I81 R85 K203 R206 G214 S215 K313 Y342 K346 Y352 K356 E373 K374
BS04	ZN	A	H394 C451 C516	H78 C135 C200

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0004000 adenosine deaminase activity

Biological Process

• GO:0006396 RNA processing

External links

• PDB: RCSB:6d06, PDBe:6d06, PDBj:6d06
• PDBsum: 6d06
• PubMed: 30581135
• UniProt: P78563|RED1_HUMAN Double-stranded RNA-specific editase 1 (Gene Name=ADARB1)