Structure of PDB 6cz7 Chain A

Receptor sequence

>6cz7A (length=814) Species: 94122 (Shewanella sp. ANA-3)

GAELPAPLRRTGVGEWLATTCQGCTSWCAKQIYVMDGRALKVRGNPNSGV
HGMSSCPRQHLSLQQVYDPDRLRTPMMRTNPKKGRDQDPKFVPISWDKAL
DMLADKIIALRVANEPHKYALLRGRYSHINDLLYKKMTNLIGSPNNISHS
SVCAEAHKMGPYYLDGNWGYNQYDVKNAKFILSFGADPIASNRQVSFYSQ
TWGDSLDHAKVVVVDPRLSASAAKAHKWIPIEPGQDSVLALAIAHVALVE
GVWHKPFVGDFIEGKNLFKAGKTVSVESFKETHTYGLVEWWNQALKDYTP
EWASKITGIDPKTIIAIAKDMGAAAPAVQVWTSRGAVMQARGTYTSISCH
ALNGLFGGIDSKGGLFPGNKTPLLKEYPEAKAYMDEIAAKGVKKEKIDQR
GRLEFPALAKGKSGGGVITANAANGIRNQDPYEIKVMLAYFNNFNFSNPE
GQRWDEALSKVDFMAHITTNVSEFSWFADVLLPSSHHMFEKWGVLDSIGN
GVAQISIQQPSIKRLWDTRIDESEIPYMLAKKLADKGFDAPWRYINEQIV
DPETGKPAADEAEFAKLMVRYLTAPLWKEDASKYGDKLSSWDEFVQKGVW
NSSPYKLEARWGKFKTETTKFEFYSKTLEKALQSHADKHKVSIDEVMKAC
DYQARGHLAFIPHYEEPYRFGDESEFPLLLVDQKSRLNKEGRTANSPWYY
EFKDVDPGDVANEDVAKFNPIDGKKFGLKDGDEIRITSPVGMLTCKAKLW
EGVRPGTVAKCFGQGHWAYGRYASAKFGVTPRGGSNNDLIADRYDRLSGA
SAFYGHIRVRVEKV

3D structure

• PDB: 6cz7 Structural and mechanistic analysis of the arsenate respiratory reductase provides insight into environmental arsenic transformations.
• Chain: A
• Resolution: 1.62 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): R98 C193 A194 R374
• Catalytic site (residue number reindexed from 1): R58 C153 A154 R334
• Enzyme Commision number: 1.20.99.1: arsenate reductase (donor).

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	SF4	A	C61 G63 C64 S66 W67 C68 K70 C96 R98 V235 S236	C21 G23 C24 S26 W27 C28 K30 C56 R58 V195 S196
BS02	MGD	A	C64 T65 R98 G225 A230 S231 N232 D255 P256 R257 P273 D276 S373 R374 G375 V721 D722 K724 R726 N728 E730 Y844	C24 T25 R58 G185 A190 S191 N192 D215 P216 R217 P233 D236 S333 R334 G335 V681 D682 K684 R686 N688 E690 Y804
BS03	MGD	A	H189 V192 C193 R374 F481 N482 N483 F484 S487 T508 T509 S512 S524 H527 D561 D722 K724 E730 G731 R732 F802 Y809 N827 F843	H149 V152 C153 R334 F441 N442 N443 F444 S447 T468 T469 S472 S484 H487 D521 D682 K684 E690 G691 R692 F762 Y769 N787 F803

Gene Ontology

Molecular Function

• GO:0016491 oxidoreductase activity
• GO:0043546 molybdopterin cofactor binding
• GO:0046872 metal ion binding
• GO:0051539 4 iron, 4 sulfur cluster binding

Cellular Component

• GO:0042597 periplasmic space

External links

• PDB: RCSB:6cz7, PDBe:6cz7, PDBj:6cz7
• PDBsum: 6cz7
• PubMed: 30104376
• UniProt: Q7WTU0|ARRA_SHESA Arsenate respiratory reductase molybdopterin-containing subunit ArrA (Gene Name=arrA)