Structure of PDB 6cz3 Chain A

Receptor sequence
>6cz3A (length=262) Species: 9606 (Homo sapiens) [Search protein sequence]
DDAERPREEFTLCRKLGSGYFGEVFEGLWKDRVQVAIKVISRDNLLHQQM
LQSEIQAMKKLRHKHILALYAVVSVGDPVYIITELMAKGSLLELLRDSDE
KVLPVSELLDIAWQVAEGMCYLESQNYIHRDLAARNILVGENTLCKVGDF
GLARLIKEDVYLSHDHNIPYKWTAPEALSRGHYSTKSDVWSFGILLHEMF
SRGQVPYPGMSNHEAFLRVDAGYRMPCPLECPPSVHKLMLTCWCRDPEQR
PCFKALRERLSS
3D structure
PDB6cz3 Small molecule inhibitors reveal PTK6 kinase is not an oncogenic driver in breast cancers.
ChainA
Resolution1.8 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D312 R316 N317 D330
Catalytic site (residue number reindexed from 1) D131 R135 N136 D149
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FLJ A R195 L197 K219 L248 L266 M267 A268 G270 L319 D330 R14 L16 K38 L67 L85 M86 A87 G89 L138 D149 MOAD: ic50=0.056uM
PDBbind-CN: -logKd/Ki=7.25,IC50=0.056uM
BindingDB: IC50=70nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:6cz3, PDBe:6cz3, PDBj:6cz3
PDBsum6cz3
PubMed29879184
UniProtQ13882|PTK6_HUMAN Protein-tyrosine kinase 6 (Gene Name=PTK6)

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