Structure of PDB 6cym Chain A

Receptor sequence
>6cymA (length=250) Species: 9606 (Homo sapiens) [Search protein sequence]
IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPW
DKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDI
ALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETGQP
SVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGG
PFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQF
3D structure
PDB6cym Reversible covalent direct thrombin inhibitors.
ChainA
Resolution2.9 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H57 D113 E216 G217 D218 S219 G220
Catalytic site (residue number reindexed from 1) H43 D99 E195 G196 D197 S198 G199
Enzyme Commision number 3.4.21.5: thrombin.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A E22 I23 G24 M25 P27 W28 D127 H130 P131 V132 C133 Y148 K149 R151 N178 M225 K226 P228 R232 W233 E8 I9 G10 M11 P13 W14 D113 H116 P117 V118 C119 Y134 K135 R137 N157 M204 K205 P207 R211 W212
BS02 71F A S219 V239 S198 V218
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0005509 calcium ion binding
Biological Process
GO:0006508 proteolysis
GO:0007596 blood coagulation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:6cym, PDBe:6cym, PDBj:6cym
PDBsum6cym
PubMed30071045
UniProtP00734|THRB_HUMAN Prothrombin (Gene Name=F2)

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