Structure of PDB 6cyc Chain A

Receptor sequence
>6cycA (length=343) Species: 9606 (Homo sapiens) [Search protein sequence]
SLYKKAGFYTKLLHDGIQPVAAIDSNFASFTYTPRSLPEDDTSMAILSML
QDMNFINNYKIDCPTLARFCLMVKKGYRDPPYHNWMHAFSVSHFCYLLYK
NLELTNYLEDIEIFALFISCMCHDLDHRGTNNSFQVASKSVLAALYSSEG
SVMERHHFAQAIAILNTHGCNIFDHFSRKDYQRMLDLMRDIILATDLAHH
LRIFKDLQKMAEVGYDRNNKQHHRLLLCLLMTSCDLSDQTKGWKTTRKIA
ELIYKEFFSQGDLEKAMGNRPMEMMDREKAYIPELQISFMEHIAMPIYKL
LQDLFPKAAELYERVASNREHWTKVSHKFTIRGLPSNNSLDFL
3D structure
PDB6cyc Structure-Guided Design and Procognitive Assessment of a Potent and Selective Phosphodiesterase 2A Inhibitor.
ChainA
Resolution1.54 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.4.17: 3',5'-cyclic-nucleotide phosphodiesterase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A H660 H696 D697 D808 H87 H123 D124 D235
BS02 FKJ A Y655 H656 L770 T805 D808 L809 Q812 I826 Q859 F862 Y82 H83 L197 T232 D235 L236 Q239 I253 Q286 F289 MOAD: ic50=14nM
PDBbind-CN: -logKd/Ki=7.85,IC50=14nM
Gene Ontology
Molecular Function
GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0008081 phosphoric diester hydrolase activity
Biological Process
GO:0007165 signal transduction

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Molecular Function
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Biological Process
External links
PDB RCSB:6cyc, PDBe:6cyc, PDBj:6cyc
PDBsum6cyc
PubMed30128073
UniProtO00408|PDE2A_HUMAN cGMP-dependent 3',5'-cyclic phosphodiesterase (Gene Name=PDE2A)

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