Structure of PDB 6cy7 Chain A

Receptor sequence
>6cy7A (length=177) Species: 9606 (Homo sapiens) [Search protein sequence]
NVAHGLAWSYYIGYLRLILPELQARIRTYNQHAVSQRLYILLPLDCGVPD
NLSMADPNIRFLDKLPQQTADRAGIKDRVYSNSIYELLENGQRAGTCVLE
YATPLQTLFAMSQYSQAGFSREDRLEQAKLFCRTLEDILADAPESQNNCR
LIAYQEPADDSSFSLSQEVLRHLRQEE
3D structure
PDB6cy7 STING Polymer Structure Reveals Mechanisms for Activation, Hyperactivation, and Inhibition.
ChainA
Resolution2.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 2BA A S162 Y163 Y167 R238 Y240 T263 S9 Y10 Y14 R78 Y80 T103 BindingDB: EC50=200nM
Gene Ontology
Biological Process
GO:0002218 activation of innate immune response
GO:0032481 positive regulation of type I interferon production

View graph for
Biological Process
External links
PDB RCSB:6cy7, PDBe:6cy7, PDBj:6cy7
PDBsum6cy7
PubMed31230712
UniProtQ86WV6|STING_HUMAN Stimulator of interferon genes protein (Gene Name=STING1)

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