Structure of PDB 6cxo Chain A

Receptor sequence
>6cxoA (length=465) Species: 10090 (Mus musculus) [Search protein sequence]
PIPIDCRMSPWSEWSECDPCLKQRFRSRSILAFGQFNGKSCVDVLGDRQG
CEPTQECEEIQENCGNDFQCETGRCIKRRLLCNGDNDCGDYSDENDCDDD
PRTPCRDRVAEESELGLTAGYGINILGMEPLRTPFDNEFYNGLCDRVRDE
KTYYRKPWNVVSLIYETKADKSFRTENYDEHLEVFKAINREKTSNFNADF
ALKFSATEVPEFKFSYFMGKNFRRLSSYFSQSKKMFVHLRGVVQLGRFVM
RNRDVVLRSTFLDDVKALPTSYEKGEYFGFLETYGTHYSTSGSLGGQYEI
VYVLDKASMKEKGVDLNDVKHCLGFNMDLGCIKTVDITRDNIIDDVISFI
RGGTREQAILLKEKILRGDKTFDKTDFANWASSLANAPALISQRMSPIYN
LIPLKIKDAYIKKQNLEKAVEDYIDEFSTKRCYPCLNGGTIILLDGQCLC
SCPMMFRGMACEIHQ
3D structure
PDB6cxo The first transmembrane region of complement component-9 acts as a brake on its self-assembly.
ChainA
Resolution2.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA A L95 N98 D100 D102 D108 E109 L80 N83 D85 D87 D93 E94
BS02 MG A S209 N212 D214 S194 N197 D199
BS03 BMA A P25 W26 R41 P10 W11 R26
Gene Ontology
Biological Process
GO:0001906 cell killing
GO:0006955 immune response
GO:0006957 complement activation, alternative pathway
GO:0006958 complement activation, classical pathway
GO:0031640 killing of cells of another organism
GO:0050778 positive regulation of immune response
GO:0051260 protein homooligomerization
Cellular Component
GO:0005576 extracellular region
GO:0005579 membrane attack complex
GO:0005615 extracellular space
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0044218 other organism cell membrane

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Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6cxo, PDBe:6cxo, PDBj:6cxo
PDBsum6cxo
PubMed30111885
UniProtP06683|CO9_MOUSE Complement component C9 (Gene Name=C9)

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