Structure of PDB 6cx0 Chain A

Receptor sequence
>6cx0A (length=619) Species: 3702 (Arabidopsis thaliana) [Search protein sequence]
QKAAALVDLAEDGIGLPVEILDQSSESARYYFIFTRLDLIWSLNYFALLF
LNFFEQPLWCEKNPKPSCKDRDYYYLGELPYLTNAESIIYEVITLAILLV
HTFFPISYEGSRIFWTSRLNLVKVACVVILFVDVLVDFLFRIAPYVRVII
FILSIRELRDTLVLLSGMLGTYLNILALWMLFLLFASWIAFVMFEDTQQG
LTVFTSYGATLYQMFILFTTSNNPDVWIPAYKSSRWSSVFFVLYVLIGVY
FVTNLILAVVYDSFKEQLAKQVSGMDQMKRRMLEKAFGLIDSDKNGEIDK
NQCIKLFEQLTNYRTLPKISKEEFGLIFDNKDEFADLCQAIALRFQKEEV
PSLQIYHSALSQQLRAFVRSPNFGYAISFILIINFIAVVVETTLDIEESS
AQKPWQVAEFVFGWIYVLEMALKIYTYGFENYWREGANRFDFLVTWVIVI
GETATFITPFSNGEWIRYLLLARMLRLIRLLMNVQRYRAFIATFITLIPS
LMPYLGTIFCVLCIYCSIGVQVFGGLGNKKLFETELAEDDYLLFNFNDYP
NGMVTLFNLLVMGNWQVWMESYKDLTGTWWSITYFVSFYVITILLLLNLV
VAFVLEAFFTELDLEEEEK
3D structure
PDB6cx0 Structural basis for activation of voltage sensor domains in an ion channel TPC1.
ChainA
Resolution3.501 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA A L609 N612 L542 N545
BS02 CA A D454 E528 D395 E464
BS03 CA A D335 D337 E341 I342 D343 Q346 D291 D293 E297 I298 D299 Q302
BS04 CA A W92 E124 D170 W59 E91 D137
BS05 FJ7 A F229 W232 Y251 F185 W188 Y207
Gene Ontology
Molecular Function
GO:0005216 monoatomic ion channel activity
GO:0005245 voltage-gated calcium channel activity
GO:0005262 calcium channel activity
GO:0005509 calcium ion binding
GO:0042802 identical protein binding
Biological Process
GO:0006811 monoatomic ion transport
GO:0006816 calcium ion transport
GO:0009845 seed germination
GO:0010119 regulation of stomatal movement
GO:0019722 calcium-mediated signaling
GO:0055085 transmembrane transport
GO:0070588 calcium ion transmembrane transport
GO:0080141 regulation of jasmonic acid biosynthetic process
Cellular Component
GO:0000325 plant-type vacuole
GO:0005773 vacuole
GO:0005774 vacuolar membrane
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0034702 monoatomic ion channel complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6cx0, PDBe:6cx0, PDBj:6cx0
PDBsum6cx0
PubMed30190435
UniProtQ94KI8|TPC1_ARATH Two pore calcium channel protein 1 (Gene Name=TPC1)

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