Structure of PDB 6cw8 Chain A

Receptor sequence
>6cw8A (length=356) Species: 7955 (Danio rerio) [Search protein sequence]
PITGLVYDQRMMLHHNMWDSHHPELPQRISRIFSRHEELRLLSRCHRIPA
RLATEEELALCHSSKHISIIKSSEHMKPRDLNRLGDEYNSIFISNESYTC
ALLAAGSCFNSAQAILTGQVRNAVAIVRPPGHHAEKDTACGFCFFNTAAL
TARYAQSITRESLRVLIVDWDVHHGNGTQHIFEEDDSVLYISLHRYEDGA
FFPNSEDANYDKVGLGKGRGYNVNIPWNGGKMGDPEYMAAFHHLVMPIAR
EFAPELVLVSAGFDAARGDPLGGFQVTPEGYAHLTHQLMSLAAGRVLIIL
EGGYNLTSISESMSMCTSMLLGDSPPSLDHLTPLKTSATVSINNVLRAHA
PFWSSL
3D structure
PDB6cw8 Discovery of the First-in-Class Dual Histone Deacetylase-Proteasome Inhibitor.
ChainA
Resolution1.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A D612 H614 D705 D171 H173 D264
BS02 FGY A H463 P464 N530 S531 H574 G582 F583 H614 F643 D705 Y745 H22 P23 N89 S90 H133 G141 F142 H173 F202 D264 Y304 PDBbind-CN: -logKd/Ki=6.57,IC50=0.27uM
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