Structure of PDB 6cvx Chain A

Receptor sequence
>6cvxA (length=200) [Search protein sequence]
GSHMASMKKKGSVVIVGRINLSGDTAYAQQTRGEEGCQETSQTGRDKNQV
EGEVQIVSTATQTFLATSINGVLWTVYHGAGTRTIASPKGPVTQMYTNVD
KDLVGWQAPQGSRSLTPCTCGSSDLYLVTRHADVIPVRRRGDSRGSLLSP
RPISYLKGSSGGPLLCPAGHAVGIFRAAVCTRGVAKAVDFIPVESLETTM
3D structure
PDB6cvx Quinoxaline-Based Linear HCV NS3/4A Protease Inhibitors Exhibit Potent Activity against Drug Resistant Variants.
ChainA
Resolution1.779 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.4.13: RNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FH4 A Q1041 Y1056 H1057 V1078 D1081 R1123 L1135 K1136 G1137 S1139 F1154 R1155 A1156 A1157 D1168 Q62 Y77 H78 V99 D102 R144 L156 K157 G158 S160 F175 R176 A177 A178 D189 MOAD: Ki=21nM
PDBbind-CN: -logKd/Ki=7.68,Ki=21nM
BS02 ZN A C1097 C1099 C1145 H1149 C118 C120 C166 H170
Gene Ontology
Molecular Function
GO:0008233 peptidase activity
GO:0008236 serine-type peptidase activity
GO:0046872 metal ion binding
Biological Process
GO:0006508 proteolysis
GO:0019062 virion attachment to host cell
GO:0019087 transformation of host cell by virus
GO:0046718 symbiont entry into host cell
Cellular Component
GO:0016020 membrane
GO:0033644 host cell membrane
GO:0044423 virion component

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6cvx, PDBe:6cvx, PDBj:6cvx
PDBsum6cvx
PubMed30034602
UniProtA0A0B4WYC6

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