Structure of PDB 6cvs Chain A

Receptor sequence
>6cvsA (length=180) Species: 9606 (Homo sapiens) [Search protein sequence]
GSHMGHWSQGLKISMQDPKMQVYKDEQVVVIKDKYPKARYHWLVLPWTSI
SSLKAVAREHLELLKHMHTVGEKVIVDFAGSSKLRFRMGYHAIPSMSHVH
LHVISQDFDSPCLKNKKHWNSFNTEYFLESQAVIEMVQEAGRVTVRDGMP
ELLKLPLRCHECQQLLPSIPQLKEHLRKHW
3D structure
PDB6cvs Mechanism of APTX nicked DNA sensing and pleiotropic inactivation in neurodegenerative disease.
ChainA
Resolution2.11 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.1.71: adenosine-5'-diphospho-5'-[DNA] diphosphatase.
3.6.1.72: DNA-3'-diphospho-5'-guanosine diphosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna A W167 Y195 K197 S255 M256 K277 H278 W7 Y35 K37 S95 M96 K117 H118
BS02 dna A S328 I329 P330 S168 I169 P170
BS03 AMP A L171 S174 D193 K194 Y195 H251 S255 M256 H260 H262 L11 S14 D33 K34 Y35 H91 S95 M96 H100 H102
BS04 ZN A C319 C322 H335 H339 C159 C162 H175 H179
Gene Ontology
Molecular Function
GO:0003824 catalytic activity

View graph for
Molecular Function
External links
PDB RCSB:6cvs, PDBe:6cvs, PDBj:6cvs
PDBsum6cvs
PubMed29934293
UniProtQ7Z2E3|APTX_HUMAN Aprataxin (Gene Name=APTX)

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