Structure of PDB 6cvp Chain A

Receptor sequence
>6cvpA (length=176) Species: 9606 (Homo sapiens) [Search protein sequence]
GHWSQGLKISMQDPKMQVYKDEQVVVIKDKYPKAHYHWLVLPWTSISSLK
AVAREHLELLKHMHTVGEKVIVDFAGSSKLRFRLGYHAIPSMSHVHLHVI
SQDFDSPCLKNKKHWNSFNTEYFLESQAVIEMVQEAGRVTVRDGMPELLK
LPLRCHECQQLLPSIPQLKEHLRKHW
3D structure
PDB6cvp Mechanism of APTX nicked DNA sensing and pleiotropic inactivation in neurodegenerative disease.
ChainA
Resolution1.999 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 3.6.1.71: adenosine-5'-diphospho-5'-[DNA] diphosphatase.
3.6.1.72: DNA-3'-diphospho-5'-guanosine diphosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna A W167 Y195 K197 S255 K277 H278 W3 Y31 K33 S91 K113 H114
BS02 dna A K276 S328 I329 K112 S164 I165
BS03 AMP A L171 S174 D193 K194 Y195 L203 H251 P254 S255 M256 H260 H262 L7 S10 D29 K30 Y31 L39 H87 P90 S91 M92 H96 H98
BS04 ZN A C319 C322 H335 H339 C155 C158 H171 H175
Gene Ontology
Molecular Function
GO:0003824 catalytic activity

View graph for
Molecular Function
External links
PDB RCSB:6cvp, PDBe:6cvp, PDBj:6cvp
PDBsum6cvp
PubMed29934293
UniProtQ7Z2E3|APTX_HUMAN Aprataxin (Gene Name=APTX)

[Back to BioLiP]