Structure of PDB 6cv7 Chain A

Receptor sequence

>6cv7A (length=365) Species: 10090 (Mus musculus) [Search protein sequence]

YDDDWQYEDCKLARGGPPATIVAIDEESRNGTILVDNMLIKGTAGGPDPT
IELSLKDNVDYWVLLDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQCVN
KKVGTVIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSG
DNGATDIDDGPNGQIEYVIQYNPEDPTSNDTFEIPLMLTGNVVLRKRLNY
EDKTRYYVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVP
NTRDCRPLTYQAAIPELRTPEELNPILVTPPIQAIDQDRNIQPPSDRPGI
LYSILVGTPEDYPRFFHMHPRTAELTLLEPVNRDFHQKFDLVIKAEQDNG
HPLPAFASLHIEILD

3D structure

PDB

6cv7 Mechanotransduction by PCDH15 Relies on a Novel cis-Dimeric Architecture.

Chain

Resolution

1.692 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	CA	A	E27 E28 D83 D85 D121	E26 E27 D82 D84 D120
BS02	CA	A	E27 D85 D118 R119 D121 D159	E26 D84 D117 R118 D120 D158
BS03	CA	A	N120 N122 D157 D159 N163 D215	N119 N121 D156 D158 N162 D214
BS04	CA	A	E137 D236 G237 D239 D289	E136 D235 G236 D238 D288
BS05	CA	A	D238 L240 D287 D289 Q348	D237 L239 D286 D288 Q347
BS06	MAN	A	Q212 R223 T225	Q211 R222 T224

Gene Ontology

	Molecular Function
GO:0005509	calcium ion binding

	Biological Process
GO:0007155	cell adhesion
GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules
GO:0007605	sensory perception of sound
GO:0048839	inner ear development

	Cellular Component
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0032420	stereocilium

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:6cv7, PDBe:6cv7, PDBj:6cv7
PDBsum	6cv7
PubMed	30057206
UniProt	Q99PJ1\|PCD15_MOUSE Protocadherin-15 (Gene Name=Pcdh15)

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